Sienna is a medium-sized town that consisted of survivors who quickly left after the infected started to overwhelm most of the town, except for the remaining part, which is owned by Isham Seely, who owns the remaining pharmacy in the town, which has some bandages, two green strain antigens, and some insulin, which is needed by Alice Ivers due to her diabetes. The Tom 'n Butch group is located south of the east part of Sienna.
- Isham Seely (Determinant)
- Isham Seely - Killed. (Determinant)
- Alice Ivers - Killed. (Determinant)
- Tom Catt - Killed. (Determinant)
- Butch Billington - Killed. (Determinant)
- Charley Parkhurst - Infected with the Invisible Strain, and later put down.
- Few unnamed survivors - Killed.